These events have been reported involving several mechanisms, including NOX4/TRPC6 (Ilatovskaya et al., 2018), Ang II/TRPC6/NFAT (Ma et al., 2019) pathways, and the rearrangement of the actin cytoskeleton in the podocytes (Wang et al., 2020) in diabetic nephropathy. The gene discussed is TRPC6; the disease is diabetic kidney disease.