Same as spontaneously hypertensive rat (SHR) and angiotensin II (Ang II)‐dependent models of hypertension, most hypertensive patients exhibit intact RBF autoregulation; they develop benign nephrosclerosis characterized by narrowing of preglomerular arterioles, which limits glomerular injury (Griffin, 2017; Hayashi et al., 1992a; Ren et al., 2010). Here, AGT is linked to hypertensive disorder.