NCF1 and hypertensive disorder: While the previous studies focused on the role of P67phox or neutrophil cytosolic factor 2 (Ncf2) in the development of hypertension because it is located on chromosome 13, it is important to recognize that both P67phox and P47phox (Ncf1) play a critical role in the activation of ROS in macrophages (Zhong et al., 2018).