SHROOM3 and chronic kidney disease: Shroom family member 3 (SHROOM3) gene has been associated with CKD in multiple GWASs (Boger et al., 2011; Kottgen et al., 2009; Prokop et al., 2018; Yeo et al., 2015), but the overall contribution of these noncoding and rare variants to CKD risk is very modest (Boger & Heid, 2011).