Other known constituents (GSK3β and mTOR) of the Akt pathway were not affected to the same degree (Data not shown). Our findings are consistent with those of Dr Vogelstein's findings20 that enhanced FOXO protein activity was correlated with reduced liver metastasis after simultaneous knockout of Akt1/2 in human colon cancer cells. The gene discussed is AKT1; the disease is colonic neoplasm.