In addition to transcription factor activity, FOXO can affect the function of other proteins through protein‐protein interactions, such as FOXO1 can directly bind to AR and inhibit its activity to affect the progression of prostate cancer,16 suggesting FOXOs might affect Akt1/2 knockout‐reduced metastasis by interfering with AR nuclear translocation. Here, FOXO1 is linked to Familial prostate cancer.