Because potyviruses are known to selectively require different eIF4E paralogs to establish infection (eIF4E, eIFiso4E, or the atypical nCBP factor) (Duprat et al., 2002; Gomez et al., 2019; Nicaise et al., 2007; Sato et al., 2005), we reasoned that reshuffling this selectivity by inactivating one paralog could affect global plant susceptibility. This evidence concerns the gene EIF4E and infection.