SERPINE1 and soft tissue neoplasm: Pseudomyogenic hemangioendothelioma (PHE) is a rare soft tissue tumor characterized by a specific recurrent balanced translocation, t(7;19)(q22;q13), which fuses SERPINE1 to FOSB. 3,4 The translocation leads to the loss of the first exon of FOSB containing the start codon, resulting in a novel start codon in exon 2 of FOSB. The translocation therefore causes the loss of 48 amino acids at the start of the FOSB protein, which then falls consequently under the control of the SERPINE1 promoter.4