MAPT and tauopathy: Although this finding contradicts the predictions of the ‘amyloid cascade hypothesis’ in which tau tangle formation is considered secondary to β-amyloid pathology (Hardy and Allsop, 1991; Selkoe, 1991), it is consistent with careful neuropathologic studies that show that tauopathy can precede beta-amyloidosis, at least in some brain areas (Duyckaerts, 2011).