Von Willebrand disease (or low von Willebrand factor) was diagnosed in 50 cases (9.0%), mild hemophilia in 14 cases (2.5%), deficiency of other coagulation factors in seven cases (1.3%; including six patients with factor XI deficiency and one patient with factor X deficiency), fibrinogen disorders in six cases (1.1%), disorders of fibrinolysis in seven cases (1.3%; including one patient with α2-antiplasmin deficiency, three patients with PAI1 deficiency and three patients with abnormal clot lysis time), anticoagulant treatment in five cases (0.9%), and a systemic disorder in 38 cases (6.9%). The gene discussed is SERPINE1; the disease is Von Willebrand disease.