These are BRCA1, BRCA2, PALB2, CDKN2A, ATM, CHEK2, APC, and MUYTH. 34 From 650 unselected patients with pancreatic neoplasms, Lowery et al. found that pathogenic germ line alterations associated with the DDR were present in 20% of patients.35 The gene discussed is BRCA1; the disease is pancreatic neoplasm.