It cannot be excluded that the predictive value of soluble α-Klotho levels, demonstrated in septic patients with chronic kidney disease [23], may result from increased cleavage and shedding of membrane bound Klotho via upregulation of disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) in severe sepsis and septic shock [24]. The gene discussed is KL; the disease is chronic kidney disease.