Serum-soluble α-Klotho levels correlate negatively with the prevalence of arteriosclerosis [7], which suggests its preventive role in the development of premature arteriosclerosis [8], potentially related to the enhanced synthesis of NO by the endothelium [9] and suppression of TNF-α-induced expression of adhesion molecules [5]. The gene discussed is TNF; the disease is arteriosclerosis.