As recovery after IS remains the point of the highest interest, we assessed soluble α-Klotho and intact FGF23 (iFGF23) and tested whether an association exists between α-Klotho serum levels and the soluble α-Klotho/iFGF23 index and the long-term IS outcomes, such as overall survival and stroke-free survival. The gene discussed is KL; the disease is stroke disorder.