The soluble α-Klotho to iFGF23 index was not a predictor of OS (crude HR = 0.999 (95% CI: 0.993–1.006), p = 0.89, and adjusted for age, obesity, type 2 diabetes, hypertension, atrial fibrillation, smoking, LDL cholesterol, eGFR, and NIHSS-I score HR = 0.999 (95% CI: 0.993–1.005), p = 0.67) or SFS (crude HR = 1.001 (95% CI: 0.996–1.007), p = 0.69, and adjusted for age, obesity diabetes, hypertension, atrial fibrillation, smoking, LDL cholesterol, eGFR, and NIHSS-I score HR = 0.999 (95% CI: 0.994–1.005), p = 0.96). This evidence concerns the gene KL and obesity due to melanocortin 4 receptor deficiency.