To extract hub proteins that were actively involved in the onset and progression of CRC, we further performed multivariate Cox regression analysis and finally identified 6 survival-related proteins, CCNE1, HER1, INPP4B, RPS6KA1, SRC, and SLC1A5, and named them hub proteins (p < 0.05). The gene discussed is EGFR; the disease is colorectal carcinoma.