The top 5 upregulated genes in tumor tissue were MMP1 (FDR = 4.77e − 53), MMP10 (FDR = 8.25e − 40), PTHLH (FDR = 1.48e − 38), MMP3 (FDR = 5.38e − 38), and SPP1 (FDR = 2.79e − 37) while TMPRSS11B (FDR = 1.53e − 36), MAL (FDR = 8.50e − 35), CRISP3 (FDR = 1.60e − 34), CRNN (FDR = 4.32e − 33), and KRT4 (FDR = 1.24e − 30) were the most significant downregulated genes. This evidence concerns the gene KRT4 and neoplasm.