PTGS2 and lung cancer: Tocotrienols are known to target and inhibit the cyclooxygenase-2 (COX-2), a proinflammatory enzyme which is activated in gastric, hepatocellular, esophageal, pancreatic, colorectal, breast, bladder, cervical, endometrial, skin, and lung cancers and is involved in promoting cell survival, angiogenesis, and metastasis [37–39].