Multivariate Cox regression analysis indicated that after adjusting for main tumor size, cirrhosis, TNM stage, BCLC stage, CLIP stage, and AFP level, the risk signature was still significantly correlated with OS survival outcome (HR = 1.807, 95%CI = 1.126–2.899, and P = 0.014), implying that the two-hub gene signature served as an independent prognostic factor for HBV-HCC patients (Table 3). Here, AFP is linked to Cirrhosis.