TNF and colorectal carcinoma: Other studies reported that levels of IL-1β, IL-18, and TNF-α were reduced through inhibiting inflammasome in colorectal carcinoma mice with inhibited MK2, leading to the reduction of inflammatory responses and suppression of tumour growth, suggesting that MK2 can promote the expression of NLRP3 inflammasome through activating TTP, thereby promoting inflammatory responses [34].