In view of the widespread evidence for hyperactivated NOX4 and Wnt/β-catenin signaling in pulmonary fibrotic procession, and involvements of silica-induced ROS production in pathogenesis of silica-related diseases, we hypothesized that the interaction between the NOX4 and Wnt/β-catenin signaling may contribute to the pathogenetic process of silica-related lung disease. Here, NOX4 is linked to lung disorder.