In the human hepatocellular carcinoma cell lines HepG2 and Huh-7, TRPV2 was found to mediate H2O2-induced oxidative stress and cell death by potentiating the inhibition of the prosurvival signaling proteins (Akt, Nrf2) and enhancing prodeath signaling proteins (p38, JNK1) [52]. The gene discussed is TRPV2; the disease is hepatocellular carcinoma.