TRPV2 silencing increased proliferation and resistance to apoptosis in the high-grade U87MG glioma cell line, which displays a predominant mesenchymal stem cell (MSC) phenotype [24], whereas overexpression of TRPV2 enhanced differentiation of glioblastoma stem-like cells (GSCs) and reduced tumor size and viability [27]. Here, TRPV2 is linked to central nervous system cancer.