The expressions of FXR, SHP, LXRα, LXRβ, CYP7A1, CYP51, and ApoE were downregulated in the NC group, and TLSP treatment reversed their expression levels (Figure 7(a)), which suggests that TLSP ameliorated hyperlipidemia and accelerated cholesterol and bile acid metabolism via the LXR/FXR-SHP/CYP7A1 signaling pathway. The gene discussed is NR1H4; the disease is hyperlipidemia.