It is found in the cytoplasm linked to regulatory proteins I Bs, in response to different stimuli, such as infection, hypoxia by oxidative stress, extracellular signals, and inflammation, and the regulatory proteins I Bs are phosphorylated by the enzyme kinase I B. The activation of NF-kB regulates inflammatory proteins and TNF and IL-1 [60]. The gene discussed is TNF; the disease is infection.