Activation of TLR9 by its ligands inhibits proinflammatory resistin secretion and TLR9 deficiency or knockdown decreases expression of anti-inflammatory adiponectin expression in mice or cultured adipocytes, respectively, suggesting that adipocytic TLR9 signaling protect inflammation associated with obesity [24]. The gene discussed is TLR9; the disease is obesity due to melanocortin 4 receptor deficiency.