We and others have shown overexpression of OSM, or administration of OSM protein results in a Th2-like phenotype (eosinophilia and IL-4, IL-5, and IL-13 cytokine production) [18–20] with an associated Arg1+ alternatively activated macrophage accumulation in the C57Bl/6 mouse lung [21]. Here, OSM is linked to Increased total eosinophil count.