Dual phosphorylation of c-Myc on Thr58 and Ser62 triggers binding to an E3 ubiquitin ligase SCF-Fbxw7 (Skp-Cullen-F-box) and consequent proteasomal degradation of c-Myc (14), thus leading to the proposed tumor suppressor role of DYRK2. Here, DYRK2 is linked to neoplasm.