TP53 and leukemia: It has been observed that some of the inbred strains, such as Balb/c and C57BL/6, are predisposed to developing certain spontaneous tumors, with lymphoma often being most common, indicating that the mouse and human T-cell adaptive immune systems have a differential dependence upon p53 to prevent a lymphoma or leukemia (Kohnken et al, 2017).