We have previously shown that down-regulation of GLIS3, a susceptibility gene for T1D and T2D development that is also causal for monogenic forms of the disease (Taha et al, 2003; Senée et al, 2006; Dimitri et al, 2011), decreases the expression of the splicing factor serine and arginine rich 6 splicing factor (SRSF6, also known as SRp55), a serine/arginine (SR) protein family member (Nogueira et al, 2013; Juan-Mateu et al, 2018). Here, SRSF6 is linked to type 2 diabetes mellitus.