GLIS3 and diabetes mellitus: As a whole, these observations support, at least in part, the hypothesis that the splicing regulator SRSF6 acts downstream of the diabetes candidate gene GLIS3. GLIS3, however, has a broad impact on β-cell phenotype and survival (Taha et al, 2003; Senée et al, 2006; Dimitri et al, 2011; Nogueira et al, 2013), which most probably goes beyond its effects on SRSF6 regulation.