In the pancreatic β-cells, SRSF6 expression is regulated by the diabetes susceptibility gene GLIS3 (Nogueira et al, 2013), which encodes an important transcription factor for β-cell development and maintenance of the differentiated phenotype (Kang et al, 2009; Wen & Yang, 2017; Scoville et al, 2020). Here, SRSF6 is linked to diabetes mellitus.