INS and early-onset autosomal dominant Alzheimer disease: A total of 30 gene sets were further enriched in KEGG and Reactome pathways (Figure 3C, Table S7) with 16 gene sets enriched in up-regulated genes related to neurological disorders and endocrine control and included ‘Parkinson’s disease’, ‘Alzheimer’s disease’, ‘opioid signaling pathway’, ‘calcium signaling pathway’, ‘thermogenesis’, ‘melanogenesis’, ‘insulin secretion’, ‘retrograde endocannabinoid signaling’ and ‘neuronal systems’.