Analysis of TCGA database showed that the CD109 transcriptional level was positively correlated with EMT-related genes, including SNAI2, ZEB1, VIM, MMP2, and TWIST1, in patients with lung adenocarcinomas (Figure 1F), and Gene Set Enrichment Analysis (GSEA) revealed that high CD109 expression in lung cancer patients was associated with the EMT signature (Figure 1G). This evidence concerns the gene TWIST1 and lung adenocarcinoma.