We further examined the clinical association between CD109 and YAP signaling from TCGA lung adenocarcinoma dataset (LUAD), and results showed that CD109 expression was positively correlated with YAP downstream targets including AXL (Pearson r = 0.539), AREG (Pearson r = 0.448), CTGF (Pearson r = 0.219), and CYR61 (Pearson r = 0.309) (Figure 6A). Here, CCN2 is linked to lung adenocarcinoma.