Interleukin-1β plays a mediating role in atherosclerosis, myocardial infarction, and heart failure; a phase III study of the monoclonal antibody canakinumab that targets this cytokine found that, in patients who had previously experienced a myocardial infarct and had elevated plasma C-reactive protein, canakinumab administration significantly lowers risk for a subsequent Myocardial infarction (MI) [5,6]. This evidence concerns the gene CRP and myocardial infarction.