SAP18 and squamous cell carcinoma: Subsequently, it was shown that S385 DNp63a phosphorylation is induced by cisplatin in squamous cell carcinoma cells, leading to RNA splicing and ACIN1-mediated cell death via interaction with spliceosome components SAP18, RBM38, ELAVL, SRPK2, SRSF2, and ACIN1 [158].