BAX and leukemia: Jacarelhyperol A caused a dose-dependent decrease in the cell viability of different types of leukemia cells, such as K 562, HL-60, and THP-1 by blocking the heterodimerization of Mcl-1 with BCL2-associated X (Bax), and Bcl-xL/Bcl-2 with Bak, with IC50 values from 1.52 to 6.92 μM [51].