The administration of HF, which has no consequence on the production of the prosurvival protein Mcl-1, provokes the interaction of Noxa with Mcl-1 and the disconnection of Mcl-1/Bak complex, showing that increased Noxa dislocates the proapoptotic protein Bak from Mcl-1. The gene discussed is PMAIP1; the disease is hydrops fetalis.