ACE2 and chronic kidney disease: Evidence for loss of cellular ACE2 via shedding was observed in various cell lines [10,11,12,26], neurons [8], myocytes [27], pancreatic islets [25], human airway epithelium [28], human cardiac myofibroblasts [29], hypertensive human brains [6], and blood [30] and urine of patients with chronic kidney disease [31].