A role for oxidative stress in the development of T2D has been largely supported by several studies [32,121,122,123,124,125]; however, oxidative damage is also associated with obesity, can also be prevented by overexpression of CuZn- or Mn-superoxide dismutase (SOD1 and SOD2, respectively) [126]. This evidence concerns the gene SOD2 and type 2 diabetes mellitus.