To discern the role of miRNAs associated with insulin sensitivity, He et al. performed a miRNA microarray analysis of skeletal muscles from either healthy or T2D rats, in which the major miR involved in insulin-stimulated glucose uptake belonged to the miR-29 family: its upregulation in diabetic animals was able to control insulin response into adipose tissue, muscle and liver. The gene discussed is INS; the disease is type 2 diabetes mellitus.