SOD2 and obesity due to melanocortin 4 receptor deficiency: In this regard, the role of miR-21, notoriously upregulated in human obesity [127,128], and diabetic milieu (including its cardiovascular complications [129,130,131,132,133,134,135,136,137]), in reducing the plasmatic amount of SOD2 was recently established, highlighting the issue of ROS-mediated damage in subjects overweight and with a high risk of developing diabetes [32]; besides, a high amount of lipid peroxidation was found in these subjects compared to normal conditions.