In the Atherosclerosis Risk in Communities Study (ARIC), both obesity and diabetes exhibit inflammatory activity mediated by adiponectin, although this topic presents conflicting aspects; on one hand, adiponectin may play the role of the protective factor for CVD and increase insulin sensitivity, but on the other hand, its endothelial activation may interfere with the production of nitric oxide (NO), inducing coronary plaque stabilization, arterial vasodilation [9] and finally promoting atherosclerosis [13,14]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.