CASP3 and Parkinson disease: Moreover, scopoletin, also present in extract, is a coumarin present in different species of plants that possess anticancer properties inducing cell cycle arrest and caspase-3 activation in the prostate cancer cell line [52], while inducing PARP cleavage and DNA fragmentation in promyeloleukemic HL-60 cells which lead to apoptosis [53]; and is able to enhance the neuronal defense system and protect the brain from rotenone-induced oxidative stress and Parkinson’s disease [54].