As noted, alterations in other cells in the tumour microenvironment can modulate CD8+ T cell and NK cell cytotoxicity, including via variations in fluxes from MDSC, tumour-associated M2-like macrophages, γδT cells, mast cells, Treg, neutrophils and dendritic cells, allowing these cells to contribute to the regulation of cytolytic cell exhaustion and immune suppression [29,30,31,61]. Here, CD8A is linked to neoplasm.