Elevations in O-GlcNAcylation are associated with increased NLRP3 inflammasome and NF-κB signalling activity [147], with the NLRP3 inflammasome important to cancer progression and tumour microenvironment regulation [132], with effects at least partly regulated by the O-GlcNAcylation of RACK1. The gene discussed is RACK1; the disease is cancer.