Consequently, SIRT1 and SIRT3 are important regulators of tumour cell survival [115,116] and cell function in the tumour microenvironment [117,118], with SIRT1 overexpression in mesenchymal stem cells (MSC) enhancing NK cell attraction, thereby shifting MSC effects from potentiating to supressing tumour progression [119]. Here, SIRT3 is linked to neoplasm.