Regarding the expression of CB1 in ovarian cancer, Messalli and coworkers [141] showed that CB1 expression was moderate in benign and borderline epithelial rat ovarian tumours, but was increased in invasive ovarian tumours, suggesting a correlation between the extent of expression of the ECS components and the prognosis for patients with more aggressive ovarian cancer [141]. This evidence concerns the gene CNR1 and ovarian neoplasm.