In support, in fructose fed rodents, the levels of blood NO are increased [85] and iNOS gene, and protein expression levels are increased in the aortas of high fructose corn syrup (HFCS) fed rodents [86], although endothelial eNOS is decreased resulting in dysregulation of vascular tone and hypertension [87]. This evidence concerns the gene NOS2 and Hypertension.