Crocin was further found to be associated with reduced expression of Krüppel-like factor 5 (KLF5) and hypoxia-inducible factor-1α (HIF-1α), two important transcription factors for the development of gastric cancer, following administration in human gastric cancer cell lines AGS and HGC-27 cells [33]. The gene discussed is KLF5; the disease is gastric cancer.