SOD1 and cancer: Moreover, increased Cu concentration is needed to potentiate the activity of cupro-enzymes like lysyl oxidase (LOX), superoxide dismutase (SOD), and cytochrome-c-oxidase (COX) as well as some molecular pathways which support cancer cell proliferation and survival, like mitogen-activated protein (MAP) kinases and autophagic ULK1/2 kinases [15].