TP53 and neoplasm: In particular, prognosis was strongly impacted by activated CD4+ T cell intraepithelial infiltration; the percentage of infiltrated tumors varies widely according to the different tumor subtypes: from 78% of HPV-positive VSCCs, to 60% of HPV-negative/TP53 wild type and 40% of HPV negative/TP53-mutated tumors [21].