The variables’ comparison between patients with MTHFR C677T polymorphism (n = 44) and patients with MTHFR A1298C polymorphism (n = 16) revealed a significant differences between groups regarding gender, male (p < 0.001), female (p < 0.001), HTN (p = 0.002), SSS/SSS+LS (p < 0.001), LS/LS+SP/LS+SS (p < 0.001), factor V-Leiden (p < 0.001), PAI-1 (p < 0.001), tHcy (p < 0.001). This evidence concerns the gene MTHFR and hypertensive disorder.