In the first group we included 60 patients with inherited thrombophilia; all of them had MTHFR gene polymorphism (C677T and/or A1298C) but some of them had other polymorphism besides MTHFR. We found 44 cases (38.59%) with MTHFR gene polymorphism C677T and 16 cases (14.03%) with MTHFR gene polymorphism A1298C; 52 cases (45.61%) presented the homozygous genotype. Here, MTHFR is linked to thrombophilia.