INS and hyperinsulinism: Initially, in our earlier work [38], the HFD/STZ treated rats showed clear hyperglycemic condition (276.74 ± 6.03 mg blood glucose/dl) and hyperinsulinemia (36.84 ± 0.58 mg insulin/dL) when compared to the control group (95.72 ± 0.42 and 11.62 ± 0.25, respectively).