The negative statistically significant relations between NT and CRP (rho = −0.84, p < 0.001), TT and CRP (rho = −0.76, p < 0.001), also IL-6 (rho = −0.18, p = 0.03), NT/TT and CRP (rho = −0.40, p = 0.02), and the positive statistically significant relations between DS/NT and CRP (rho = 0.40, p = 0.02) and DS/TT and CRP (rho = 0.40, p = 0.02) showed alteration of thiol-disulfide homeostasis in relation with inflammation in renal cancer. The gene discussed is IL6; the disease is renal carcinoma.