One recent study [5] developed a proteomic research, investigating the urinary N-glycoproteome of clear cell renal cell carcinoma at different evolution stages and showed an up-expression of P13P1, CD97, COCH and a down-expression of haptoglobin, fibronectin, ceruloplasmin, apolipoprotein B, phospholipids transfer protein, H factor of complement according to the RCC stage. The gene discussed is COCH; the disease is renal cell carcinoma.