More recently, Wang et al. reported that nuclear reporter subfamily 2, group F and member 2 (NR2F2), a protein involved in the development of several cancers [148], inhibited Smad7 expression and induced a TGF-β-dependent EMT of CRC cells [149], further underlining the dual role of Smad7 in the early and late stages of CRC development [96]. This evidence concerns the gene SMAD7 and cancer.