In the latter study, T-ALL tumour cells were generated in vitro by retroviral expression of an oncogenic NOTCH1 mutant in mouse haematopoietic stem cells that also carried a floxed Prkaa1 (AMPK-α1) gene and a Cre recombinase gene driven by a tamoxifen-inducible promoter. This evidence concerns the gene PRKAA1 and acute lymphoblastic leukemia.