As for example, single point mutations of adiponectin (T45G) in exon 2 (rs2241766) and G276T in intron 2 (rs1501299) are genetic determinants shown to be closely associated with the CV risk path, most probably due to its effect on adiponectin plasma levels, particularly resulting in hypoadiponectinemia [37]. The gene discussed is ADIPOQ; the disease is adiponectin deficiency.