Likewise, Western blot analysis indicated that basal expression (under isosmotic conditions) p38-MAPK and p42/44-MAPK increased significantly in glaucoma LC cells, and in response to hyposmotic-induced cellular swelling, the relative activity (phosphorylation) of p38-MAPK and p42/44-MAPK significantly increased in normal and glaucoma LC cells; however, the response to hyposmotic-induced cell swelling was more exaggerated in glaucoma LC cells for both protein kinases. The gene discussed is WEE1; the disease is glaucoma.