Figure 4 summarizes evaluation of apoptosis (cytoplasmic cleaved caspase-3 expression, Bax and Bcl-2), proliferation (Ki67 expression), angiogenesis markers (vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) expression, and anti-oxidant activity of R. coriaria (malondialdehyde (MDA) levels) in rat mammary carcinoma cells in vivo. Here, KDR is linked to breast carcinoma.