IL10 and COVID-19: By examining temporal and spatial characteristics of monocytes in African green monkey and rhesus macaque animal models with COVID-19, Fahlberg et al. [185] characterized an initial acute hyperinflammatory state with increased frequency of CD16+ monocytes in the lungs, followed by a gradual switch to a type 2 response, and corresponding increase in either anti-inflammatory IL-10 associated with disease resolution, or IL-6, which is associated with increased disease severity [185].