AGT and COVID-19: Moreover, an early investigation of epidemiological, clinical, laboratory, and radiological markers of COVID-19 disease severity in China found that elevated serum Ang II was positively correlated with viral load and lung injury in COVID-19 [115], likely due to AT1R activation as well as endothelial cell death by oxidative stress and ubiquitin-proteasome-mediated proteolysis [116,117,118].