CircPAN3, which is a circular RNA, mediates the development of acute myeloid leukemia (AML) drug resistance, and the inhibition of cricPAN3 resensitizes the drug resistance to doxorubicin by modulating autophagy, which is regulated by the AMPK/mTOR pathway, and inducing apoptosis-related proteins in ADM-resistant cells [114]. This evidence concerns the gene MTOR and acute myeloid leukemia.