From the data of a cohort focused on patients with SPINK1 mutations, the cancer risk was 12-times higher in patients than in controls, and the cumulative rates of pancreatic cancer before 50, 60, 70, and 80 years of age were 0.8%, 11.9%, 27.7%, and 51.8%, respectively [7]. This evidence concerns the gene SPINK1 and familial pancreatic carcinoma.