Metformin has been reported to regulate the G0/G1 cell-cycle arrest in myeloma cell lines in vitro by inducing autophagy via activated AMPK and repressing both the mTORC1 and mTORC2 signaling pathways via p-4EBP1, p-AKT, and TSC2 [38]. The gene discussed is EIF4EBP1; the disease is plasma cell myeloma.