Based on the results in Figure 2 and Figure 3, we further investigated the association between circulating adiponectin and obesity by comparison of ORs (95% CIs) calculated with a logistic regression model with adjustment for confounding factors (i.e., age, cigarette smoking, alcohol consumption, menopausal status, and total calorie intake). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.