CD274 and glioblastoma: Pembrolizumab, a humanized monoclonal IgG4 anti PD-1 antibody, was tested in a phase II trial presented at the ASCO 2018 meeting, as monotherapy or in combination with bevacizumab in recurrent bevacizumab-naive GBM patients at first or second recurrence, regardless of PD-L1 expression [115].